Oprozomib | 2386

Oprozomib is a next generation, irreversible and selective proteasome inhibitor that displays potent anti-myeloma properties. It potently induces apoptosis in HNSCC cell lines via upregulation of pro-apoptotic Bik.

Oprozomib is a next generation, irreversible and selective proteasome inhibitor that displays potent anti-myeloma properties.

2386 | Oprozomib DataSheet

Alternate Name/Synonyms: N-((S)-3-methoxy-1-(((S)-3-methoxy-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)-2-methylthiazole-5-carboxamide; ONX-0912; PR-047

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 935888-69-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₃₂N₄O₇S

Molecular Weight: 532.61

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~100 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A next generation proteasome inhibitor

MDL Number: N/A

PubChem CID: 25067547

SMILES: CC1=NC=C(S1)C(=O)NC(COC)C(=O)NC(COC)C(=O)NC(CC2=CC=CC=C2)C(=O)C3(CO3)C

InChi: InChI=1S/C25H32N4O7S/c1-15-26-11-20(37-15)24(33)29-19(13-35-4)23(32)28-18(12-34-3)22(31)27-17(21(30)25(2)14-36-25)10-16-8-6-5-7-9-16/h5-9,11,17-19H,10,12-14H2,1-4H3,(H,27,31)(H,28,32)(H,29,33)/t17-,18-,19-,25+/m0/s1

InChi Key: SWZXEVABPLUDIO-WSZYKNRRSA-N