OPRS1 Antibody (N-term) [APR05067G]

OPRS1 Antibody (N-term) [APR05067G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This OPRS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-81 amino acids from the N-terminal region of human OPRS1.

Cellular Localisation: Nucleus inner membrane. Nucleus outer membrane. Nucleus envelope. Cytoplasmic vesicle. Endoplasmic reticulum membrane. Membrane; Single-pass membrane protein. Lipid droplet {ECO:0000250|UniProtKB:O55242}. Cell junction. Cell membrane. Cell projection, growth cone. Cell junction, synapse, postsynaptic density membrane. Note=During interphase, detected at the inner and outer nuclear membrane and the endoplasmic reticulum Detected on cytoplasmic vesicles during mitosis (PubMed:10406945) Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Accumulation at the endoplasmic reticulum is prominent in alpha-motor neurons of patients with amyotrophic lateral sclerosis (PubMed:23314020) . Enriched at cell-cell communication regions, growth cone and postsynaptic structures Localization is modulated by ligand-binding. In motor neurons it is enriched at cholinergic postsynaptic densities (By similarity) {ECO:0000250|UniProtKB:O55242, ECO:0000269|PubMed:10406945, ECO:0000269|PubMed:23314020}

Molecular Weight: 25128

Clone: Polyclonal

Gene Name: SIGMAR1

Gene ID: 10280

Function: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:16472803, PubMed:9341151) . Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity) .

Summary: Tissue Location: Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas Expressed in the retina by retinal pigment epithelial cells. Expressed in alpha-motor neurons (PubMed:23314020) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC

Dilution: WB--1:1000 FC--1:10~50

Synonyms: Sigma non-opioid intracellular receptor 1, Aging-associated gene 8 protein, SR31747-binding protein, SR-BP, Sigma 1-type opioid receptor, SIG-1R, Sigma1-receptor, Sigma1R, hSigmaR1, SIGMAR1, OPRS1, SRBP