LBD
ORAI1 Antibody (C-term) [APR17665G]
- SKU:
- LBD-APR17665G
- Availability:
- Usually ships in 5 working days
Description
ORAI1 Antibody (C-term) [APR17665G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This ORAI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 269-298 amino acids from the C-terminal region of human ORAI1.
Cellular Localisation: Cell membrane; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8BWG9}; Multi-pass membrane protein. Note=Isoform beta is more mobile in the plasma membrane (PubMed:23307288) . Colocalizes with STIM1 at the cell membrane (PubMed:27185316) .
Molecular Weight: 32668
Clone: Polyclonal
Gene Name: ORAI1
Gene ID: 84876
Function: Ca (2+) release-activated Ca (2+) (CRAC) channel subunit which mediates Ca (2+) influx following depletion of intracellular Ca (2+) stores and channel activation by the Ca (2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928, PubMed:20354224, PubMed:26956484) . CRAC channels are the main pathway for Ca (2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901) . Plays a prominent role in Ca (2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca (2+) content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca (2+) for milk secretion.
Summary: Tissue Location: Expressed in naive CD4 and CD8 T cells (at protein level) (PubMed:26956484) . Expressed at similar levels in naive and effector T helper cells (PubMed:20354224)
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Calcium release-activated calcium channel protein 1, Protein orai-1, Transmembrane protein 142A, ORAI1, CRACM1, TMEM142A