ORAI1 Antibody (Center) [APR17666G]

ORAI1 Antibody (Center) [APR17666G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This ORAI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-173 amino acids of human ORAI1.

Cellular Localisation: Cell membrane; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8BWG9}; Multi-pass membrane protein. Note=Isoform beta is more mobile in the plasma membrane (PubMed:23307288) . Colocalizes with STIM1 at the cell membrane (PubMed:27185316) .

Molecular Weight: 32668

Clone: Polyclonal

Gene Name: ORAI1

Gene ID: 84876

Function: Ca (2+) release-activated Ca (2+) (CRAC) channel subunit which mediates Ca (2+) influx following depletion of intracellular Ca (2+) stores and channel activation by the Ca (2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928, PubMed:20354224, PubMed:26956484) . CRAC channels are the main pathway for Ca (2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901) . Plays a prominent role in Ca (2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca (2+) content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca (2+) for milk secretion.

Summary: Tissue Location: Expressed in naive CD4 and CD8 T cells (at protein level) (PubMed:26956484) . Expressed at similar levels in naive and effector T helper cells (PubMed:20354224)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Calcium release-activated calcium channel protein 1, Protein orai-1, Transmembrane protein 142A, ORAI1, CRACM1, TMEM142A