Orai1 polyclonal Antibody | BS90988

Orai1 polyclonal Antibody | BS90988 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Application: WB ICC IHC FC

Application Range: WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: Orai1 (ORAI calcium release-activated calcium modulator 1), also known as ORAT1, CRACM1 (calcium release-activated calcium modulator 1) or TMEM142A (transmembrane protein 142A), is a 301 amino acid multi-pass membrane protein that belongs to the Orai family of proteins. Localizing to the plasma membrane, Orai1 plays an important role in store-operated calcium (SOC) entry, a process involving Ca2+ influx and replenishment of Ca2+ stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca2+ mobilizing agents. Specifically, Orai1 functions as a pore subunit of the store-operated calcium release-activated calcium channel (CRAC) and is essential for proper function of the CRAC channel. CRAC channels are responsible for mediating calcium influx in T-cells and play an important role in the immune response. Mutations in the gene encoding Orai1 can result in severe combined immunodeficiency (SCID) .

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: Orai1 polyclonal Antibody detects endogenous levels of Orai1 protein.

Molecular Weight: 33 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ORAI1, CRACM1, TMEM142A, Calcium release activated calcium channel protein 1, Calcium release activated calcium modulator 1, Calcium release-activated calcium channel protein 1, CRACM 1, CRACM1, CRCM1, CRCM1, FLJ14466, Orai 1, ORAI calcium release activated calcium modulator 1, orai1, ORAT1, Protein orai 1, Protein orai-1, TMEM 142A, TMEM142A, Transmembrane protein 142A,

Immunogen: Synthetic peptide within mouse Orai1 aa 150-250.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Peptide affinity purified.

Pathway: