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Orai1 polyclonal Antibody | BS90988
- SKU:
- BW-BS90988
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- Usually ships in 5 working days
Description
Orai1 polyclonal Antibody | BS90988 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human, Mouse
Application: WB ICC IHC FC
Application Range: WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100
Background: Orai1 (ORAI calcium release-activated calcium modulator 1), also known as ORAT1, CRACM1 (calcium release-activated calcium modulator 1) or TMEM142A (transmembrane protein 142A), is a 301 amino acid multi-pass membrane protein that belongs to the Orai family of proteins. Localizing to the plasma membrane, Orai1 plays an important role in store-operated calcium (SOC) entry, a process involving Ca2+ influx and replenishment of Ca2+ stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca2+ mobilizing agents. Specifically, Orai1 functions as a pore subunit of the store-operated calcium release-activated calcium channel (CRAC) and is essential for proper function of the CRAC channel. CRAC channels are responsible for mediating calcium influx in T-cells and play an important role in the immune response. Mutations in the gene encoding Orai1 can result in severe combined immunodeficiency (SCID) .
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Specificity: Orai1 polyclonal Antibody detects endogenous levels of Orai1 protein.
Molecular Weight: 33 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: ORAI1, CRACM1, TMEM142A, Calcium release activated calcium channel protein 1, Calcium release activated calcium modulator 1, Calcium release-activated calcium channel protein 1, CRACM 1, CRACM1, CRCM1, CRCM1, FLJ14466, Orai 1, ORAI calcium release activated calcium modulator 1, orai1, ORAT1, Protein orai 1, Protein orai-1, TMEM 142A, TMEM142A, Transmembrane protein 142A,
Immunogen: Synthetic peptide within mouse Orai1 aa 150-250.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Peptide affinity purified.
Pathway: