OSI-027 | 2372

OSI-027 is a potent mammalian target of rapamycin (mTOR) kinase inhibitor with potential antineoplastic activity. It binds to and inhibits both the raptor-mTOR (TOR complex 1 or TORC1) and the rictor-mTOR (TOR complex 2 or TORC2) complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation.

OSI-027 is a potent mammalian target of rapamycin (mTOR) kinase inhibitor with potential antineoplastic activity.

2372 | OSI-027 DataSheet

Alternate Name/Synonyms: 4-(4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid; ASP4786

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 936890-98-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₂N₆O₃

Molecular Weight: 406.44

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~18 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A potent mTOR inhibitor

MDL Number: MFCD20275101

PubChem CID: 44224160

SMILES: COC1=CC=CC2=CC(=C3C4=C(N=CNN4C(=N3)C5CCC(CC5)C(=O)O)N)N=C21

InChi: InChI=1S/C21H22N6O3/c1-30-15-4-2-3-13-9-14(25-16(13)15)17-18-19(22)23-10-24-27(18)20(26-17)11-5-7-12(8-6-11)21(28)29/h2-4,9-12H,5-8,22H2,1H3,(H,23,24)(H,28,29)/b17-14-

InChi Key: CDNMDRUIGNHEMR-VKAVYKQESA-N