OSM polyclonal Antibody | BS7949

OSM polyclonal Antibody | BS7949 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB,IHC,IF

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Background: Oncostatin M (OSM) is a glycoprotein that was originally isolated from the conditioned medium of U937 human histiocytic leukemia cells that had been induced to differentiate into macrophage-like cells by treatment with phorbol 12-myristate 13 acetate. OSM inhibits the growth of a broad range of human tumor cell lines, but does not influence the growth of normal human fibroblasts. High-affinity binding sites for OSM have been detected on normal and tumor cells, and a receptor has been identified by chemical cross-linking studies. Expression of OSM is greatest in activated monocytic and lymphocytic cell lines and in normal adherent macrophages. Amino acid sequence analysis of OSM has revealed homology with leukemia inhibitory factor (LIF), granulocyte colony stimulating factor (G-CSF) and interleukin 6 (IL-6), all of which affect the growth and differentiation of a broad range of cell types, including those of hematopoietic origin.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: OSM polyclonal Antibody detects endogenous levels of OSM protein.

Molecular Weight: ~ 28 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ONCM_HUMAN; Oncostatin M; Oncostatin-M; OSM;

Immunogen: Recombinant full length Human OSM.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: