Description
OSS-128167 is a potent and selective inhibitor of sirtuin 6 (SIRT6; IC50 = 89 μM). It displays selectivity for SIRT6 over SIRT1 and SIRT2 (IC50s = 1,578 and 751 μM, respectively). OSS-128167 increases acetylation of histone H3 lysine 9 (H3K9) and glucose uptake and decreases TNF-α release in BxPC-3 cells.
OSS-128167 is a potent and selective inhibitor of sirtuin 6 (SIRT6; IC50 = 89 μM). It displays selectivity for SIRT6 over SIRT1 and SIRT2 (IC50s = 1,578 and 751 μM, respectively). OSS-128167 increases acetylation of histone H3 lysine 9 (H3K9) and glucose uptake and decreases TNF-α release in BxPC-3 cells.
Alternate Name/Synonyms: 5-[[3-[(2-furanylcarbonyl)amino]benzoyl]amino]-2-hydroxy-benzoic acid,OSS128167
Appearance: Crystalline solid
Formulation:
CAS Number: 887686-02-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₁₄N₂O₆
Molecular Weight: 366.3
Cell-Permeable?: TRUE
Purity: ≥98% by HPLC
Solubilities: ~30 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent and selective SIRT6 (Sirtuin-6) inhibitor
MDL Number:
PubChem CID: 6496840
SMILES: C1=CC(=CC(=C1)NC(=O)C2=CC=CO2)C(=O)NC3=CC(=C(C=C3)O)C(=O)O
InChi: InChI=1S/C19H14N2O6/c22-15-7-6-13(10-14(15)19(25)26)20-17(23)11-3-1-4-12(9-11)21-18(24)16-5-2-8-27-16/h1-10,22H,(H,20,23)(H,21,24)(H,25,26)
InChi Key: HTJWLEGCECXGSQ-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |