OSS-128167 | B2761

OSS-128167 is a potent and selective inhibitor of sirtuin 6 (SIRT6; IC50 = 89 μM). It displays selectivity for SIRT6 over SIRT1 and SIRT2 (IC50s = 1,578 and 751 μM, respectively). OSS-128167 increases acetylation of histone H3 lysine 9 (H3K9) and glucose uptake and decreases TNF-α release in BxPC-3 cells.

OSS-128167 is a potent and selective inhibitor of sirtuin 6 (SIRT6; IC50 = 89 μM). It displays selectivity for SIRT6 over SIRT1 and SIRT2 (IC50s = 1,578 and 751 μM, respectively). OSS-128167 increases acetylation of histone H3 lysine 9 (H3K9) and glucose uptake and decreases TNF-α release in BxPC-3 cells.

B2761 | OSS-128167 DataSheet

Alternate Name/Synonyms: 5-[[3-[(2-furanylcarbonyl)amino]benzoyl]amino]-2-hydroxy-benzoic acid,OSS128167

Appearance: Crystalline solid

Formulation:

CAS Number: 887686-02-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₄N₂O₆

Molecular Weight: 366.3

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: ~30 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective SIRT6 (Sirtuin-6) inhibitor

MDL Number:

PubChem CID: 6496840

SMILES: C1=CC(=CC(=C1)NC(=O)C2=CC=CO2)C(=O)NC3=CC(=C(C=C3)O)C(=O)O

InChi: InChI=1S/C19H14N2O6/c22-15-7-6-13(10-14(15)19(25)26)20-17(23)11-3-1-4-12(9-11)21-18(24)16-5-2-8-27-16/h1-10,22H,(H,20,23)(H,21,24)(H,25,26)

InChi Key: HTJWLEGCECXGSQ-UHFFFAOYSA-N