OTS-964 | B1964

OTS-964 is a potent inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK; IC₅₀ = 28 nM). It specifically blocks cytokinesis, leading to apoptosis, in a broad range of cancer cells. OTS-964 induces apoptosis of human lung cancer cells in mouse xenografts.

OTS-964 is a potent inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK; IC₅₀ = 28 nM). It specifically blocks cytokinesis, leading to apoptosis, in a broad range of cancer cells. OTS-964 induces apoptosis of human lung cancer cells in mouse xenografts.

B1964 | OTS-964 DataSheet

Alternate Name/Synonyms: (R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-one

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1338545-07-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₂N₂O₂S

Molecular Weight: 378.49

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A ptent inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK)

MDL Number: N/A

PubChem CID: 67449676

SMILES: CC(CN(C)C)C1=CC=C(C=C1)C2=C(C=CC3=C2C4=C(C(=O)N3)SC=C4)O

InChi: InChI=1S/C22H22N2O2S/c1-13(12-24(2)3)14-4-6-15(7-5-14)19-18(25)9-8-17-20(19)16-10-11-27-21(16)22(26)23-17/h4-11,13,25H,12H2,1-3H3,(H,23,26)/t13-/m0/s1

InChi Key: WGYWHJPQFQGLOQ-ZDUSSCGKSA-N