LBD
OTUD4 Antibody (N-term) [APR05694G]
- SKU:
- LBD-APR05694G
- Availability:
- Usually ships in 5 working days
Description
OTUD4 Antibody (N-term) [APR05694G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This OTUD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 403-430 amino acids from the N-terminal region of human OTUD4.
Cellular Localisation: Cytoplasm. Nucleus. Note=Primarily cytoplasmic
Molecular Weight: 124045
Clone: Polyclonal
Gene Name: OTUD4 (HGNC:24949)
Gene ID: 54726
Function: Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066) . May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066) . Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase- substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P
Dilution: WB--1:1000 IHC-P--1:100~500
Synonyms: OTU domain-containing protein 4, HIV-1-induced protein HIN-1, OTUD4, HIN1, KIAA1046