Description
A potent inhibitor of mammalian histone deacetylases (HDACs) (IC₅₀ = 15.7 nM). A novel antitumor agent; oxamflatin modifies epigenetic status and gene expression, increases blastocyst quality, and subsequently enhances the nuclear reprogramming and developmental potential of SCNT (somatic cell nuclear transfer) embryos.
Oxamflatin is a potent inhibitor of mammalian histone deacetylases (HDACs) (IC₅₀ = 15.7 nM) and an antitumor agent.
Alternate Name/Synonyms: N-hydroxy-5-[3-[(phenylsulfonyl)amino]phenyl]-2E-penten-4-ynamide; Metacept 3
Appearance: White to Off-white Solid
Formulation: N/A
CAS Number: 151720-43-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₇H₁₄N₂O₄S
Molecular Weight: 342.37
Cell-Permeable?: Yes
Purity: ≥95%
Solubilities: DMSO (5 mg/ml) or EtOH (0.5 mg/ml)
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: A potent inhibitor of mammalian histone deacetylases (HDACs)
MDL Number: MFCD00949087
PubChem CID: 5353852
SMILES: C1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC(=C2)C#CC=CC(=O)NO
InChi: InChI=1S/C17H14N2O4S/c20-17(18-21)12-5-4-7-14-8-6-9-15(13-14)19-24(22,23)16-10-2-1-3-11-16/h1-3,5-6,8-13,19,21H,(H,18,20)/b12-5+
InChi Key: QRPSQQUYPMFERG-LFYBBSHMSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |