p-nitro-Pifithrin-α | B2845

p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α. Pifithrin-α is an inhibitor of p53 that blocks p53-dependent apoptosis. p-nitro-Pifithrin-α blocks p53-mediated expression of p21/WAF1 and apoptosis in cortical neurons more potently than pifithrin-α. It suppresses the expression of TGF-β1 in human proximal tubular cells (HK-2 cells) at a concentration of 10 μM. It reduces hepatic triglyceride accumulation and lipotoxicity in mice fed a high fat diet.

p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α. Pifithrin-α is an inhibitor of p53 that blocks p53-dependent apoptosis. p-nitro-Pifithrin-α blocks p53-mediated expression of p21/WAF1 and apoptosis in cortical neurons more potently than pifithrin-α. It suppresses the expression of TGF-β1 in human proximal tubular cells (HK-2 cells) at a concentration of 10 μM. It reduces hepatic triglyceride accumulation and lipotoxicity in mice fed a high fat diet.

B2845 | p-nitro-Pifithrin-α DataSheet

Alternate Name/Synonyms: 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-nitrophenyl)ethanone,hydrobromide; 1-(4-Nitrophenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone, HBr; Pifithrin-alpha, p-Nitro hydrobromide; p-nitro-PFT-α

Appearance: A crystalline solid

Formulation:

CAS Number: 389850-21-9

Structure Available?: true

Peptide sequence:

Salt Form: False

Molecular Formula: C₁₅H₁₆BrN₃O₃S

Molecular Weight: 398.3

Cell-Permeable?: True

Purity: ≥95%

Solubilities: ~1mg/ml in DMSO and DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of p53

MDL Number:

PubChem CID: 11553038

SMILES: C1CCC2=C(C1)N(C(=N)S2)CC(=O)C3=CC=C(C=C3)[N+](=O)[O-].Br

InChi: InChI=1S/C15H15N3O3S.BrH/c16-15-17(12-3-1-2-4-14(12)22-15)9-13(19)10-5-7-11(8-6-10)18(20)21;/h5-8,16H,1-4,9H2;1H

InChi Key: NXPCMOGORSWOLH-UHFFFAOYSA-N