P1,P5-Di(adenosine-5′)-pentaphosphate ammonium salt | B2754

P1,P5-di(adenosine-5′)-pentaphosphate ammonium salt is a potent inhibitor of heat shock protein 78 in Leishmania donovani (LdHSP78). LdHSP78 is a putative ClpB protease, that is important for parasite infection of host macrophages and a potential therapeutic target. Enrichment of LdHSP78 in infected humans, hamsters and parasite amastigotes suggested its importance for disease persistence.

P1,P5-di(adenosine-5′)-pentaphosphate ammonium salt is a potent inhibitor of heat shock protein 78 in Leishmania donovani (LdHSP78). LdHSP78 is a putative ClpB protease, that is important for parasite infection of host macrophages and a potential therapeutic target. Enrichment of LdHSP78 in infected humans, hamsters and parasite amastigotes suggested its importance for disease persistence.

B2754 | P1,P5-Di(adenosine-5′)-pentaphosphate ammonium salt DataSheet

Alternate Name/Synonyms: A(5′)P5(5′)A, Diadenosine pentaphosphate ammonium salt

Appearance: White to off-white solid

Formulation:

CAS Number: 102783-61-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₉N₁₀O₂P₅ · xNH₃ · yH₂O

Molecular Weight: 916.37

Cell-Permeable?: TRUE

Purity: ≥95% by HPLC

Solubilities: ~50 mg/ml Water

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A HSP78 inhibitor

MDL Number:

PubChem CID: 71434041

SMILES: C1=CC(OC1COP(=O)(O)OP(=O)(O)OP)N2C=NC3=C(N=CN=C32)N

InChi: InChI=1S/C10H14N5O8P3/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(21-7)3-20-25(16,17)23-26(18,19)22-24/h1-2,4-7H,3,24H2,(H,16,17)(H,18,19)(H2,11,12,13)/t6-,7+/m0/s1

InChi Key: LWOSDYWLTWLFID-NKWVEPMBSA-N