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P1,P5-Di(adenosine-5′)-pentaphosphate ammonium salt | B2754
- SKU:
- 26-B2754-GEN
- Availability:
- Usually shipped in 5 working days
Description
P1,P5-di(adenosine-5′)-pentaphosphate ammonium salt is a potent inhibitor of heat shock protein 78 in Leishmania donovani (LdHSP78). LdHSP78 is a putative ClpB protease, that is important for parasite infection of host macrophages and a potential therapeutic target. Enrichment of LdHSP78 in infected humans, hamsters and parasite amastigotes suggested its importance for disease persistence.
P1,P5-di(adenosine-5′)-pentaphosphate ammonium salt is a potent inhibitor of heat shock protein 78 in Leishmania donovani (LdHSP78). LdHSP78 is a putative ClpB protease, that is important for parasite infection of host macrophages and a potential therapeutic target. Enrichment of LdHSP78 in infected humans, hamsters and parasite amastigotes suggested its importance for disease persistence.
B2754 | P1,P5-Di(adenosine-5′)-pentaphosphate ammonium salt DataSheet
Alternate Name/Synonyms: A(5′)P5(5′)A, Diadenosine pentaphosphate ammonium salt
Appearance: White to off-white solid
Formulation:
CAS Number: 102783-61-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₀H₂₉N₁₀O₂P₅ · xNH₃ · yH₂O
Molecular Weight: 916.37
Cell-Permeable?: TRUE
Purity: ≥95% by HPLC
Solubilities: ~50 mg/ml Water
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A HSP78 inhibitor
MDL Number:
PubChem CID: 71434041
SMILES: C1=CC(OC1COP(=O)(O)OP(=O)(O)OP)N2C=NC3=C(N=CN=C32)N
InChi: InChI=1S/C10H14N5O8P3/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(21-7)3-20-25(16,17)23-26(18,19)22-24/h1-2,4-7H,3,24H2,(H,16,17)(H,18,19)(H2,11,12,13)/t6-,7+/m0/s1
InChi Key: LWOSDYWLTWLFID-NKWVEPMBSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |