p16INK4a Antibody (C-term E119) [APR03602G]

p16INK4a Antibody (C-term E119) [APR03602G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This p16INK4a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-131 amino acids from the C-terminal region of human p16INK4a.

Cellular Localisation: Cytoplasm. Nucleus

Molecular Weight: 16533

Clone: Polyclonal

Gene Name: CDKN2A (HGNC:1787)

Gene ID: 1029

Function: Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.

Summary: Tissue Location: Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC, IHC-P-Leica

Dilution: IHC-P-Leica--1:500 WB--1:2000

Synonyms: Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3, Cyclin-dependent kinase 4 inhibitor A, CDK4I, Multiple tumor suppressor 1, MTS-1, p16-INK4a, p16-INK4, p16INK4A, CDKN2A, CDKN2, MTS1