P2RX7 Antibody (C-term) [APR32186G]

P2RX7 Antibody (C-term) [APR32186G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This P2RX7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 563-592 amino acids of human P2RX7.

Cellular Localisation: Cell membrane; Multi-pass membrane protein

Molecular Weight: 68585

Clone: Polyclonal

Gene Name: P2RX7

Gene ID: 5027

Function: Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206) .

Summary: Tissue Location: Widely expressed with highest levels in brain and immune tissues.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: P2X purinoceptor 7, P2X7, ATP receptor, P2Z receptor, Purinergic receptor, P2RX7