p38 beta, Active | 7763

p38- is a member of the p38 MAP kinase family and is activated by both proinflammatory cytokines and environmental stress (1). The p38- is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase (2). Alternatively spliced transcript variants encoding the same protein have been observed.

7763 | p38 beta Active DataSheet

Biomolecule/Target: N/A

Synonyms: p38, mitogen-activated protein kinase 11

Alternates names: Transcription factor AP-1, (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)

Taglines: Involved in a wide variety of cellular processes

NCBI Gene ID #: 3725

NCBI Gene Symbol: JUN; AP1; c-Jun

Gene Source: Human

Accession #: P05412

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 90%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: N/A

Activity (Specifications/test method): C-Jun fusion protein at a concentration of 2 µg/20 µl reaction was phosphorylated in an in vitro kinase assay with 200 µM ATP. After 30 minutes incubation at 30°C, phosphorylation was detected by Western blot with phospho-specific c-Jun antibodies.

Biological activity:

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 37.0 kDa

Concentration: 2 mg/ml

Appearance: Liquid

Physical form description: 2 mg/ml in storage buffer containing 20 mM Tris-HCl (pH 7.5), 50 mM NaCl, 2 mM EDTA, 1 mM DTT, and 50% glycerol.

Reconstitution Instructions: N/A

Amino acid sequence: N/A