P505-15 hydrochloride | 9583

P505-15 is a potent, cell-permeable, highly selective, small molecule SYK inhibitor (IC₅₀ = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases. P505-15 blocks B cell receptor-mediated cell signaling and activation in whole blood (IC₅₀s = 0.27 and 0.28 µM, respectively), as well as Fcɛ receptor 1-mediated basophil degranulation (IC₅₀ = 0.15 µM).

P505-15 hydrochloride is a potent, cell-permeable, highly selective, small molecule SYK inhibitor (IC₅₀ = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases. P505-15 blocks B cell receptor-mediated cell signaling and activation in whole blood (IC₅₀s = 0.27 and 0.28 µM, respectively), as well as Fcɛ receptor 1-mediated basophil degranulation (IC₅₀ = 0.15 µM).

9583 | P505-15 hydrochloride DataSheet

Alternate Name/Synonyms: 2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide hydrochloride; PRT062607; PRT2607; BIIB-057

Appearance: White solid

Formulation: N/A

CAS Number: 1370261-97-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₂₃N₉O. HCl

Molecular Weight: 429.91

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, cell-permeable, highly selective, small molecule SYK inhibitor

MDL Number: N/A

PubChem CID: 56948527

SMILES: C1CCC(C(C1)N)NC2=NC=C(C(=N2)NC3=CC=CC(=C3)N4N=CC=N4)C(=O)N.Cl

InChi: InChI=1S/C19H23N9O.ClH/c20-15-6-1-2-7-16(15)26-19-22-11-14(17(21)29)18(27-19)25-12-4-3-5-13(10-12)28-23-8-9-24-28;/h3-5,8-11,15-16H,1-2,6-7,20H2,(H2,21,29)(H2,22,25,26,27);1H/t15-,16+;/m0./s1

InChi Key: RMNLLPXCNDZJMJ-IDVLALEDSA-N