BW
p53 Mutant polyclonal Antibody | BS91004
- SKU:
- BW-BS91004
- Availability:
- Usually ships in 5 working days
Description
p53 Mutant polyclonal Antibody | BS91004 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human
Application: WB IHC FC IP ICC IF
Application Range: WB:1:500 IHC:1:100 FC:1:50-1:100 ICC:1:100-1:500
Background: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: p53 Mutant polyclonal Antibody detects endogenous levels of p53 Mutant protein.
Molecular Weight: 53 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: TP53, P53, Antigen NY-CO-13, BCC7, Cellular tumor antigen p53, LFS1, Mutant tumor protein 53, p53 tumor suppressor, P53, Phosphoprotein p53, Tp53, Transformation related protein 53, TRP53, Tumor protein p53, Tumor suppressor p53,
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: