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p54nrb polyclonal Antibody | BS91006
- SKU:
- BW-BS91006
- Availability:
- Usually ships in 5 working days
Description
p54nrb polyclonal Antibody | BS91006 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB ICC IF IHC
Application Range: WB:1:500-1:2,000 ICC:1:50 IHC:1:50-1:200
Background: Found in both primary and transformed human cells, paraspeckles are discrete bodies in the interchromatin nucleoplasmic space which contain p54/nrb (nuclear RNA-binding protein) and at least two other RNA-binding proteins, paraspeckle protein 1 (PSP1) and paraspeckle protein 2 (PSP2) . Paraspeckles often co-localize with splicing speckles, which are the site of splicing factor accumulation. Paraspeckle proteins, including p54/nrb, move dynamically between the nucleolus and paraspeckles and translocate to distinct caps in the nucleolar periphery when transcription is inhibited. Originally purified from HeLa cells, the nuclear p54/nrb has two RNA recognition motifs and shares extensive homology with both the human splicing factor PSF and Drosophila NONA/BJ6, which is required for normal vision and courtship. The shared domain between these proteins is termed a DBHS (Drosophila behavior, human splicing) domain and may play a role in regulating various pathways at the level of pre-mRNA splicing.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Specificity: p54nrb polyclonal Antibody detects endogenous levels of p54nrb protein.
Molecular Weight: 54 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: NonO protein, p54nrb, NONO, NRB54, 52 kDa subunit, 54 kDa nuclear RNA and DNA binding protein, 54 kDa nuclear RNA- and DNA-binding protein, 55 kDa nuclear protein, DNA binding p52/p100 complex 52 kDa subunit, DNA-binding p52/p100 complex, NMT 55, NMT55, Non Pou domain containing octamer (ATGCAAAT) binding protein, Non POU domain containing octamer binding, Non POU domain containing octamer binding protein, Non-POU domain-containing octamer-binding protein, Nono, NonO protein, NONO, NRB 54, NRB, NRB54, Nuclear RNA binding protein 54kD, P54, p54 (nrb), p54nrb, PPP1R114, Protein phosphatase 1 regulatory subunit 114,
Immunogen: Recombinant protein of C-terminal human p54nrb.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: