PAC-1 | 1654

Procaspase-activating compound 1 (PAC-1) directly activates procaspase-3 to caspase-3, a transformation that allows induction of apoptosis even in cells that have defective apoptotic machinery. In cancer cells, PAC-1 had an IC₅₀ value of 3 nM for induction of cell death, whereas in cells from adjacent normal tissue had IC₅₀ values of 3.2-8.5 µM.

PAC-1 is a Procaspase-activating compound 1 (PAC-1) directly activates procaspase-3 to caspase-3, a transformation that allows induction of apoptosis even in cells that have defective apoptotic machinery.

1654 | PAC-1 DataSheet

Alternate Name/Synonyms: 2-[[2-Hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide 4-(phenylmethyl)-1-piperazineacetic acid

Appearance: White solid

Formulation: N/A

CAS Number: 315183-21-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₈N₄O₂

Molecular Weight: 392.49

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A pro-caspase-3 activator

MDL Number: MFCD03302441

PubChem CID: 6851947

SMILES: C=CCC1=CC=CC(=CNNC(=O)CN2CCN(CC2)CC3=CC=CC=C3)C1=O

InChi: InChI=1S/C23H28N4O2/c1-2-7-20-10-6-11-21(23(20)29)16-24-25-22(28)18-27- 14-12-26(13-15-27)17-19-8-4-3-5-9-19/h2-6,8-11,16,24H,1,7,12-15,17-18H2, (H,25,28)/b21-16-

InChi Key: XSGXRYNZNGUGEJ-PGMHBOJBSA-N