PACRG Antibody | 16-343

PACRG Antibody | 16-343 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 150-250 of human PACRG (NP_001073847.1) .

Research Area: Cell Cycle, Neuroscience

Tested Application: WB

Application: WB: 1:500 - 1:2000

Specificiy: N/A

Positive Control 1: 293T

Positive Control 2: A-549

Positive Control 3: BxPC-3

Positive Control 4: Raji

Positive Control 5: Mouse testis

Positive Control 6: Mouse lung

Molecular Weight: Observed: 35kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: PACRG, GLUP, HAK005771, PARK2 co-regulated, PARK2CRG, RP3-495O10.2, PARK2 coregulated gene protein

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.