PACS2 Antibody | 8189

PACS2 Antibody | 8189 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: PACS2 antibody was raised against a 17 amino acid peptide near the center of human PACS2.
The immunogen is located within amino acids 330 - 380 of PACS2.

Research Area: Homeostasis

Tested Application: E, WB, IHC-P, IF

Application: PACS2 antibody can be used for detection of PACS2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Specificiy: PACS2 antibody is human, mouse and rat reactive. At least three isoforms of PACS2 are known to exist; this antibody will detect all three. PACS2 antibody is predicted to not cross-react with PACS1.

Positive Control 1: Cat. No. 1403 - Mouse Brain Tissue Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 98 kDa
Observed: 95 kDa

Validation: N/A

Isoform: N/A

Purification: PACS2 antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PACS2 antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: PACS2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: Phosphofurin acidic cluster sorting protein 2, PACS-2, PACS1-like protein, PACS1L

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: PACS2 (phosphofurin acidic cluster sorting protein-2) , PACS1L, is an 889 amino acid protein that localizes to both the mitochondrion and the lumen of the endoplasmic reticulum (ER) and belongs to the PACS family (1, 2) . It is expressed in a broad range of tissues with highest expression in skeletal muscle, brain, heart, testis and pancreas (2, ) . PACS2 interacts with Polycystin-2 and BID and functions as a sorting protein that regulates mitochondria-ER communication and is thought to be involved in ion channel trafficking, specifically direct cluster-containing ion channels to distinct subcellular compartments (3-5) .