PAK5 (E693) polyclonal Antibody | BS9193

PAK5 (E693) polyclonal Antibody | BS9193 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: PAK5, a member of the PAK family of protein kinases contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at the C-terminus. PAK5 preferentially binds to CDC42 in the presence of GTP and the CRIB motif is essential for this interaction. PAK5 operates downstream of Cdc42 and Rac and antagonizes Rho in the pathway, leading to neurite development. PAK5 is a functional protein kinase, but, unlike PAK-I family kinases (PAK1, 2, and 3), the kinase activity of PAK5 does not seem to require the binding of CDC42. PAK5 is highly expressed in mammalian brain but is not expressed in most other tissues. PAK5 colocalizes and binds to both the actin and MT networks and its subcellular localization is regulated during cell cycle progression.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PAK5 (E693) polyclonal Antibody detects endogenous levels of PAK5 protein.

Molecular Weight: ~ 90 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Serine/threonine-protein kinase PAK 7; p21-activated kinase 5; PAK-5; p21-activated kinase 7; PAK-7; PAK7; KIAA1264; PAK5

Immunogen: Synthetic peptide, corresponding to amino acids 660-712 of Human PAK5.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Regulation of Microtubule Dynamics,Adherens Junction signaling,