PANK2 Antibody (N-term) [APR08921G]

PANK2 Antibody (N-term) [APR08921G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-95 amino acids from the N-terminal region of human PANK2.

Cellular Localisation: [Isoform 1]: Mitochondrion. Mitochondrion intermembrane space. Nucleus Note=Localizes predominantly to the mitochondria and to a lesser extent to the nucleus. Found in both the mitochondria and the nucleus throughout the cell cycle, with the exception of the G2/M phase when it is restricted to mitochdondria. [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:12554685, ECO:0000305}

Molecular Weight: 62681

Clone: Polyclonal

Gene Name: PANK2

Gene ID: 80025

Function: [Isoform 1]: Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis (PubMed:15659606, PubMed:17825826, PubMed:17242360, PubMed:16272150) . Required for angiogenic activity of umbilical vein of endothelial cells (HUVEC) (PubMed:30221726) .

Summary: Tissue Location: Expressed in the brain (at protein level) (PubMed:15659606, PubMed:17825826) . Ubiquitous (PubMed:11479594) Highly expressed in the testis (PubMed:17825826) . Expressed in the umbilical vein endothelial cells (HUVEC) (PubMed:30221726)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Pantothenate kinase 2, mitochondrial, hPanK2, Pantothenic acid kinase 2, PANK2, C20orf48