PANX1 polyclonal Antibody | BS8352

PANX1 polyclonal Antibody | BS8352 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IF

Application Range: WB: 1:500~1:2000 IF: 1:50~1:200

Background: Gap junctions are formed by a hexameric group of proteins called connexins for the transport of low molecular weight proteins from cell to cell. Connexins, which are present in all metazoan organisms, serve diverse functions ranging from control of cell growth and differentiation to electric conduction in excitable tissues. Several mammalian cells with malignant phenotypes exhibit decreased connexin expression and gap junction communication. The pannexin gene family encodes a second class of putative gap junction proteins. Pannexins are highly conserved in invertebrates and mammals, indicating the importance of their gap junctional coupling function. Mammalian Pannexin-1 and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. Pannexin-1 is a transmembrane protein that forms calcium-permeable gap junctions between adjacent cells and in the endoplasmic reticulum. In erythrocytes, Pannexin-1 forms a mechanosensitive ATP-permeable channel in the nonjunctional plasma membrane.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PANX1 polyclonal Antibody detects endogenous levels of PANX1 protein.

Molecular Weight: ~ 45, 60 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Pannexin-1; PANX1; MRS1; UNQ2529; PRO6028

Immunogen: Recombinant full length Human PANX1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: