Paquinimod | B2617

Paquinimod is a small molecule quinoline-3-carboxamide derivative that acts as a S100A9 inhibitor. It targets the S100A9 protein and disrupts its binding to the pro-inflammatory receptors, Receptor for Advanced Glycation Endproducts (RAGE) and Toll-like Receptor 4 (TLR4). Both RAGE and TLR4 are involved in the pathogenesis of many autoimmune and inflammatory diseases and paquinimod has shown convincing beneficial effects in several autoimmune/inflammatory disease models.

Paquinimod is a small molecule quinoline-3-carboxamide derivative that acts as a S100A9 inhibitor. It targets the S100A9 protein and disrupts its binding to the pro-inflammatory receptors, Receptor for Advanced Glycation Endproducts (RAGE) and Toll-like Receptor 4 (TLR4). Both RAGE and TLR4 are involved in the pathogenesis of many autoimmune and inflammatory diseases and paquinimod has shown convincing beneficial effects in several autoimmune/inflammatory disease models.

B2617 | Paquinimod DataSheet

Alternate Name/Synonyms: ABR‑215757, ABR215757, N,5-diethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide

Appearance: White to off-white solid

Formulation:

CAS Number: 248282-01-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₂N₂O₃

Molecular Weight: 350.,42

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >50 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent S100A9 inhibitor

MDL Number:

PubChem CID: 54684617

SMILES: CCC1=C2C(=CC=C1)N(C(=O)C(=C2O)C(=O)N(CC)C3=CC=CC=C3)C

InChi: InChI=1S/C21H22N2O3/c1-4-14-10-9-13-16-17(14)19(24)18(20(25)22(16)3)21(26)23(5-2)15-11-7-6-8-12-15/h6-13,24H,4-5H2,1-3H3

InChi Key: DIKSYHCCYVYKRO-UHFFFAOYSA-N