PARP polyclonal Antibody | BS91017

PARP polyclonal Antibody | BS91017 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC/IF IHC FC

Application Range: WB:1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa) . PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: PARP polyclonal Antibody detects endogenous levels of PARP protein.

Molecular Weight: 113/89 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: PARP-1, ARTD1, ADPRT 1, PARP1, ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase), ADP ribosyltransferase diphtheria toxin like 1, ADP ribosyltransferase NAD (+), ADPRT 1, ADPRT, ADPRT1, ARTD1, msPARP, NAD (+) ADP ribosyltransferase 1, NAD (+) ADP-ribosyltransferase 1, pADPRT 1, pADPRT1, PARP 1, PARP, PARP-1, PARP1, PARP1, Poly (ADP ribose) polymerase 1, poly (ADP ribose) polymerase family, member 1, Poly [ADP-ribose] polymerase 1, Poly (ADP ribose) polymerase, poly (ADP ribose) synthetase, poly (ADP ribosyl) transferase, Poly[ADP ribose] synthetase 1, Poly[ADP-ribose] synthase 1, PPOL,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: