PARP1 Antibody, KO Validated | 13-327

PARP1 Antibody, KO Validated | 13-327 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 81-390 of human PARP1 (NP_001609.2) .

Research Area: Cell Cycle, Immunology, Signal Transduction

Tested Application: WB, IHC, IF, IP, CHIP

Application: WB: 1:1000 - 1:3000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200
IP: 1:50 - 1:200
CHIP: 1:50 - 1:200

Specificiy: N/A

Positive Control 1: Jurkat

Positive Control 2: HeLa

Positive Control 3: RAW264.7

Positive Control 4: C6

Positive Control 5: Mouse testis

Positive Control 6: Mouse brain

Molecular Weight: Observed: 100kDa, 110kDa, 125kDa

Validation: Antibody is Knockout validated.

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: KIF3B, PARP, PPOL, ADPRT, ARTD1, ADPRT1, PARP-1, ADPRT 1, pADPRT-1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly (ADP-ribosyl) ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.