PARP1 polyclonal Antibody | BS91018

PARP1 polyclonal Antibody | BS91018 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Application: WB ICC FC

Application Range: WB:1:500 ICC:1:50-1:100 FC:1:50-1:100

Background: Involved in the base excision repair (BER) pathway, by catalyzing the poly (ADP-ribosyl) ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly (ADP-ribosyl) ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: PARP1 polyclonal Antibody detects endogenous levels of PARP1 protein.

Molecular Weight: 113 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: PARP-1, ARTD1, ADPRT 1, PARP1, ADPRT, PPOL, ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase), ADP ribosyltransferase, ADP ribosyltransferase diphtheria toxin like 1, ADP ribosyltransferase NAD (+), ADPRT 1, ADPRT, ADPRT1, ARTD1, msPARP, NAD (+) ADP ribosyltransferase 1, NAD (+) ADP-ribosyltransferase 1, pADPRT 1, pADPRT1, PARP 1, PARP, PARP-1, PARP1, PARP1, Poly (ADP ribose) polymerase 1, poly (ADP ribose) polymerase family, member 1, Poly [ADP-ribose] polymerase 1 Antibody Poly (ADP ribose) polymerase, poly (ADP ribose) synthetase, poly (ADP ribosyl) transferase, Poly[ADP ribose] synthetase 1, Poly[ADP-ribose] synthase 1, PPOL,

Immunogen: Synthetic peptide within PARP1 aa 200-250.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Peptide affinity purified.

Pathway: