PATL1 Antibody (C-term) [APG02948G]

PATL1 Antibody (C-term) [APG02948G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PATL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 489-518 amino acids from the C-terminal region of human PATL1.

Cellular Localisation: Cytoplasm, P-body. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic (PubMed:22090346) . Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner (PubMed:22090346) . Enriched in splicing speckles Localization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus (PubMed:22090346)

Molecular Weight: 86850

Clone: Polyclonal

Gene Name: PATL1

Gene ID: 219988

Function: RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261) . Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261) . Required for cytoplasmic mRNA processing body (P- body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261) .

Summary: Tissue Location: Ubiquitous..

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: Protein PAT1 homolog 1, PAT1-like protein 1, Protein PAT1 homolog b, Pat1b, hPat1b, PATL1