LBD
PAX6 Antibody (Center) [APR12741G]
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- LBD-APR12741G
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Description
PAX6 Antibody (Center) [APR12741G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This PAX6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 183-214 amino acids from the Central region of human PAX6.
Cellular Localisation: Nucleus {ECO:0000250|UniProtKB:P63015}. [Isoform 5a]: Nucleus {ECO:0000250|UniProtKB:P63016}
Molecular Weight: 46683
Clone: Polyclonal
Gene Name: PAX6
Gene ID: 5080
Function: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity) . Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity) . Acts as a transcriptional repressor of NFATC1- mediated gene expression (By similarity) .
Summary: Tissue Location: [Isoform 1]: Expressed in lymphoblasts.
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Paired box protein Pax-6, Aniridia type II protein, Oculorhombin, PAX6, AN2