PD-0325901 | 1643

A selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC₅₀ = 0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal of embryonic stem (ES) cells.

PD-0325901 is a selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC₅₀ = 0.33 nM).

1643 | PD-0325901 DataSheet

Alternate Name/Synonyms: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2[(2-fluoro-4-iodophenyl)amino]-benzamide

Appearance: Off-white solid

Formulation: N/A

CAS Number: 391210-10-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₄F₃IN₂O₄

Molecular Weight: 482.2

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (20 mg/ml) of EtOH (20 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A MEK inhibitor

MDL Number: MFCD08435926

PubChem CID: 9826528

SMILES: C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O

InChi: InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1

InChi Key: SUDAHWBOROXANE-SECBINFHSA-N