PD-0332991 isethionate | 9480

PD0332991 is a highly specific inhibitor of Cdk4 (IC₅₀ = 11 nM) and Cdk6 (IC₅₀ = 16 nM). Displays selectivity for Cdk4/6 over a panel of 34 additional protein kinases (IC₅₀ values are > 10 μM).

PD0332991 is a highly specific inhibitor of Cdk4 (IC₅₀ = 11 nM) and Cdk6 (IC₅₀ = 16 nM). Displays selectivity for Cdk4/6 over a panel of 34 additional protein kinases (IC₅₀ values are > 10 μM).

9480 | PD-0332991 isethionate DataSheet

Alternate Name/Synonyms: 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one isethionate salt; Palbociclib

Appearance: Yellow solid

Formulation: N/A

CAS Number: 827022-33-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₄H₂₉N₇O₂.C₂H₆O₄S

Molecular Weight: 573.66

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: Water (~55 mg/ml) or DMSO (~ 6 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A highly specific inhibitor of Cdk4 and Cdk6

MDL Number: N/A

PubChem CID: 11478676

SMILES: CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.C(CS(=O)(=O)O)O

InChi: InChI=1S/C24H29N7O2.C2H6O4S/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32;3-1-2-7(4,5)6/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29);3H,1-2H2,(H,4,5,6)

InChi Key: LYYVFHRFIJKPOV-UHFFFAOYSA-N