PD-166285 dihydrochloride | B2094

PD-166285 is a potent, ATP-competitive and broadly active protein tyrosine kinase inhibitor. It inhibits tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β(PDGFRβ) (IC₅₀ values are 8.4, 39.3 and 98.3 nM respectively). PD-166285 also displays inhibitory activity against mitogen-activated protein kinase (IC₅₀ = 5 μM) and protein kinase C (IC₅₀ = 22.7 μM).

PD-166285 is a potent, ATP-competitive and broadly active protein tyrosine kinase inhibitor. It inhibits tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β(PDGFRβ) (IC₅₀ values are 8.4, 39.3 and 98.3 nM respectively). PD-166285 also displays inhibitory activity against mitogen-activated protein kinase (IC₅₀ = 5 μM) and protein kinase C (IC₅₀ = 22.7 μM).

B2094 | PD-166285 dihydrochloride DataSheet

Alternate Name/Synonyms: 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride

Appearance: Yellow solid

Formulation: N/A

CAS Number: 212391-63-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₂₇Cl₂N₅O₂.2HCl

Molecular Weight: 612.37

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, ATP-competitive and broadly active protein tyrosine kinase inhibitor

MDL Number: MFCD18086890

PubChem CID: 9916391

SMILES: CCN(CC)CCOC1=CC=C(C=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl.Cl.Cl

InChi: InChI=1S/C26H27Cl2N5O2.2ClH/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28;;/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31);2*1H

InChi Key: NADLBPWBFGTESN-UHFFFAOYSA-N