PD-166866 | B2223

PD-166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) (IC₅₀ = 55 nM). It has no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4. Displays antiproliferative and anti-angiogenic activities.

PD-166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) (IC₅₀ = 55 nM). It has no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4. Displays antiproliferative and anti-angiogenic activities.

B2223 | PD-166866 DataSheet

Alternate Name/Synonyms: 1-[2-Amino-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl urea

Appearance: Off-white to light tan solid

Formulation: N/A

CAS Number: 192705-79-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₄N₆O₃

Molecular Weight: 396.44

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective FGF-1 receptor tyrosine kinase (FGFR1) inhibitor

MDL Number: MFCD12922514

PubChem CID: 5328127

SMILES: CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=CC(=CC(=C3)OC)OC

InChi: InChI=1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)

InChi Key: NHJSWORVNIOXIT-UHFFFAOYSA-N