PD-168393 | B2352

PD-168393 is a cell-permeable, irreversible inhibitor of EGFR kinase activity (IC₅₀ = 0.70 nM). PD-168393 decreases the production of TNF-α and phosphorylation of ERK1/2 and p38 induced by LPS in cardiomyocytes.

PD-168393 is a cell-permeable, irreversible inhibitor of EGFR kinase activity (IC₅₀ = 0.70 nM). PD-168393 decreases the production of TNF-α and phosphorylation of ERK1/2 and p38 induced by LPS in cardiomyocytes.

B2352 | PD-168393 DataSheet

Alternate Name/Synonyms: PD168393,N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-propenamide

Appearance: White to off-white solid

Formulation:

CAS Number: 194423-15-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₇H₁₃BrN₄O

Molecular Weight: 369.2

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >25 mg/ml (DMSO) in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent, EGFR kinase inhibitor

MDL Number: MFCD02179207

PubChem CID: 4708

SMILES: C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br

InChi: InChI=1S/C17H13BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h2-10H,1H2,(H,21,23)(H,19,20,22)

InChi Key: HTUBKQUPEREOGA-UHFFFAOYSA-N