PD 173074 | 1675

A potent and selective FGFR1 tyrosine kinase inhibitor (IC₅₀ = 21.5 nM). Blocking of the FGFR signaling pathway by PD 173074 leads to self-renewal of stem cells via ERK1/2 activation. Treatment of FGF2-expressing human multipotent adipose-derived stem cells with PD173074 decreases dramatically their clonogenicity and differentiation potential.

PD173074 is a potent and selective FGFR1 tyrosine kinase inhibitor (IC₅₀ = 21.5 nM). Blocking of the FGFR signaling pathway by PD 173074 leads to self-renewal of stem cells via ERK1/2 activation.

1675 | PD 173074 DataSheet

Alternate Name/Synonyms: N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N’-(1,1-dimethylethyl)urea

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 219580-11-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₄₁N₇O₃

Molecular Weight: 523.67

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A FGFR1 kinase inhibitor

MDL Number: MFCD11045982

PubChem CID: 1401

SMILES: CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C

InChi: InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)

InChi Key: DXCUKNQANPLTEJ-UHFFFAOYSA-N