PD1 monoclonal Antibody (Humanized) | AP6666

PD1 monoclonal Antibody (Humanized) | AP6666 | Gentaur UK, US & Europe Distribution

Host: Human

Reactivity: Human

Application: Neutralization/Block

Application Range: Neutralization/Block

Background: The humanized monoclonal anti-PD1 Antibody can effectively block the combination between PDL1 and PD1, and will not cause HAMA reaction (anti mouse Antibody response) . Programmed cell death protein 1 (PD-1) (UniProt Q15116), is a type I single transmembrane protein encoded by the PDCD1 gene in human. T-cell activation is generally self-limited as activated T cells express receptors such as PD-1. Maintenance of peripheral tolerance by preventing the development of autoimmunity due to T lymphocytes specific for self-antigens is essential for homeostasis of the immune system. PD-1 can bind two different but related ligands, PDL-1 and PDL-2.PD-1 receptor and its ligands PD-L1 and PD-L2play a vital role in the induction and maintenance of peripheral tolerance. The humanized monoclonal anti-PD1 Antibody has demonstrated durable antitumor activity.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PD1 monoclonal Antibody (Humanized) detects endogenous levels of human PD1 protein. Variable region genes (including VH &VL) of this Antibody were derived from a single B cell by PCR.

Molecular Weight: ~ 32 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Programmed cell death protein 1; Protein PD-1; hPD-1; CD279; PDCD1; PD1

Immunogen: Variable region genes (including VH &VL) of this Antibody were derived from a single B cell by PCR.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Recombinant IgG antibodies were expressed and secreted by 293F cells and purified by Protein A.

Pathway: