PD184352 | 1585

A highly potent ATP-noncompetitive MEK inhibitor. It inhibits MEK with an in vitro IC₅₀ of 1-1.3 nM. It does not inhibit other kinases. Highly recommended tool to inhibit MKK1 or MKK1 plus MKK5.

PD184352 is a highly potent ATP-noncompetitive MEK inhibitor. It inhibits MEK with an in vitro IC₅₀ of 1-1.3 nM. It does not inhibit other kinases.

1585 | PD184352 DataSheet

Alternate Name/Synonyms: CI-1040

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 212631-79-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₄ClF₂IN₂O₂

Molecular Weight: 478.67

Cell-Permeable?: Yes

Purity: ≥99% by HPLC

Solubilities: DMSO (600 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A MEK inhibitor

MDL Number: MFCD02683961

PubChem CID: 6918454

SMILES: C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl

InChi: InChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)

InChi Key: GFMMXOIFOQCCGU-UHFFFAOYSA-N