PDE1A monoclonal Antibody | MB64403

PDE1A monoclonal Antibody | MB64403 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat

Application: IHC, WB

Application Range: WB 1:2000, IHC 1:150

Background: Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca (2+) /calmodulin (see CALM1; MIM 114180) -dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca (2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]) . [supplied by OMIM, Oct 2009]

Storage & Stability: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: phosphodiesterase 1A

Molecular Weight: 62.1 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A

Immunogen: Human recombinant protein fragment corresponding to amino acids 259-545 of human PDE1A (NP_005010) produced in E.coli.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A