PDE4C polyclonal Antibody | BS5844

PDE4C polyclonal Antibody | BS5844 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB ICC

Application Range: WB: 1:500~1:1000 ICC: 1:50~1:200

Background: Phosphodiesterases (PDE) hydrolyze cAMP to 5’AMP and thus play a critical role in the regulation of intracellular cAMP. Division of the PDE superfamily by sequence homology and enzymatic properties yields 11 PDE families. A unique upstream conserved region (UCR) characterizes the PDE4 family. Four separate genes (A-D) encode the PDE4 enzymes, and alternative splicing generates short or long isoforms of each gene. Long PDE4 isoforms contain both UCR1 and UCR2 while short PDE4 isoforms possess only UCR2. Both UCR domains are necessary for dimerization of PDE4 isoforms. The human PDE4C gene maps to chromosome 19p13.1. The splice variants include isoforms PDE4C1-7.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PDE4C polyclonal Antibody detects endogenous levels of PDE4C protein.

Molecular Weight: ~ 80 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: cAMP-specific 3',5'-cyclic phosphodiesterase 4C; DPDE1; PDE21; DPDE1

Immunogen: Synthetic peptide, corresponding to amino acids 333-378 of Human PDE4C.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: