PDE6B Antibody | 22-572

PDE6B Antibody | 22-572 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human PDE6B (NP_001138763.1) .

Research Area: Neuroscience, Signal Transduction

Tested Application: WB, IHC, IF

Application: WB: 1:500 - 1:2000
IHC: 1:50 - 1:100
IF: 1:50 - 1:100

Specificiy: N/A

Positive Control 1: Mouse liver

Positive Control 2: Mouse pancreas

Positive Control 3: Mouse heart

Positive Control 4: Rat liver

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed: 98kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: CSNB3, CSNBAD2, GMP-PDEbeta, PDEB, RP4rd1, rod cGMP-specific 3', 5'-cyclic phosphodiesterase subunit beta, GMP-PDE beta, phosphodiesterase 6B, cGMP-specific, rod, beta, rod cGMP-phosphodiesterase beta-subunit

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE) , resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.