PDGFB Polyclonal Antibody | E-AB-40267

PDGFB Polyclonal Antibody | E-AB-40267 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: Becaplermin, PDGF 2, PDGF B chain, PDGF subunit B, PDGF-2, PDGF2, Pdgfb, PDGFB, Platelet derived growth factor 2, Platelet-derived growth factor B chain, Platelet-derived growth factor beta polypeptide, Platelet-derived growth factor subunit B, Proto-oncogene c-Sis, SIS, SSV

Application: IHC

Reactivity: Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cardiovascular, Metabolism, Developmental Biology, Signal Transduction

Background: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Concentration: 0.83 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant Rat Platelet-derived growth factor subunit B protein

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Purification Method: Antigen Affinity Purification

Dilution: IHC 1:100-1:200

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A