PDL1 ELISA Matched Antibody Pair (Risk Free) | RFP-0306

PDL1 ELISA Matched Antibody Pair (Risk Free) | RFP-0306 | Gentaur UK, US & Europe Distribution

Host: Multiple

Reactivity: Human

Homology: N/A

Immunogen: PD-L1 antibodies were raised against the extracellular domain of human PD-L1.

Tested Application: E

Application: N/A

Specificity: N/A

Purification: Mouse Monoclonal: Antibodies supplied as protein A purified IgG1.

Single Domain: Antibodies supplied as affinity chromatography purified via nickel column.

Clonality: Monoclonal

Isotype: IgG1 and sdab

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS containing 0.02% sodium azide.

Concentration: Antibody 1 mg/mL

Storage Condition: Mouse Monoclonal: Antibodies can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Single Domain: Antibody should be stored in working aliquots at -20˚C, stable for up to one year.

As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Background: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. ProSci's Risk-FreeTM antibodies are mouse monoclonal antibodies made to improve in vivo studies. Unlike antibodies developed using proteins made in yeast or bacteria, Risk-FreeTM antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. Validated for flow cytometry and ELISA Rigorously tested for the following applications: Immunoblot Immunohistochemistry Immunocytochemistry Immunofluorescence Multiple antibodies per target allowing the user to choose the best antibody for their application Available individually or as a set Risk-FreeTM means they are guaranteed to work for their approved applications

User Note: Optimal dilutions for each application to be determined by the researcher.