Description
PEN2 polyclonal Antibody | BS9960M | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IHC ICC FC
Application Range: WB: 1:500-1:2000 IHC: 1:50-1:200 ICC: 1:50-1:200 FC: 1:50-1:100
Background: Four proteins comprise the gamma-secretase complex: presenilin, nicastrin, aph-1, and PEN-2. Together, these proteins mediate cell surface signaling pathways for a variety of type I membrane proteins, notably amyloid-beta precursor protein, a protein implicated in the development of Alzheimer's disease, via intramembrane proteolysis. The proteins assemble into a proteolytically active complex in the golgi/trans-golgi network (TGN) compartments. Assembly leads to autocleavage of presenilin into two subunits to create the active site of gamma-secretase, an important step in understanding the mechanisms involved in the etiology and possible treatment of Alzheimer's disease.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This Antibody detects endogenous levels of PEN2 and does not cross-react with related proteins.
Molecular Weight: ~ 12 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Gamma-secretase subunit PEN-2; Presenilin enhancer protein 2; PSENEN; PEN2; MDS033
Immunogen: Synthetic peptide corresponding to C-terminal human PEN2.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Protein A affinity purified.
Pathway: