PEN2 polyclonal Antibody | BS9960M

PEN2 polyclonal Antibody | BS9960M | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC ICC FC

Application Range: WB: 1:500-1:2000 IHC: 1:50-1:200 ICC: 1:50-1:200 FC: 1:50-1:100

Background: Four proteins comprise the gamma-secretase complex: presenilin, nicastrin, aph-1, and PEN-2. Together, these proteins mediate cell surface signaling pathways for a variety of type I membrane proteins, notably amyloid-beta precursor protein, a protein implicated in the development of Alzheimer's disease, via intramembrane proteolysis. The proteins assemble into a proteolytically active complex in the golgi/trans-golgi network (TGN) compartments. Assembly leads to autocleavage of presenilin into two subunits to create the active site of gamma-secretase, an important step in understanding the mechanisms involved in the etiology and possible treatment of Alzheimer's disease.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This Antibody detects endogenous levels of PEN2 and does not cross-react with related proteins.

Molecular Weight: ~ 12 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Gamma-secretase subunit PEN-2; Presenilin enhancer protein 2; PSENEN; PEN2; MDS033

Immunogen: Synthetic peptide corresponding to C-terminal human PEN2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein A affinity purified.

Pathway: