Penciclovir | B2704

Penciclovir is a synthetic acyclic guanine derivative with antiviral activity used for the treatment of various herpes simplex virus (HSV) infections. It displays activity against multiple laboratory and clinical isolate strains of herpes simplex virus 1 (HSV-1), HSV-2, and varicella zoster virus (VZV) in a plaque reduction assay (IC50s = 0.4-3.1 μg/ml). Penciclovir inhibits HSV-1 and HSV-2 replication (IC99s = 0.4 and 0.7 μg/ml, respectively) and DNA synthesis (IC50 = 0.04 μg/ml) in MRC-5 cells.

Penciclovir is a synthetic acyclic guanine derivative with antiviral activity used for the treatment of various herpes simplex virus (HSV) infections. It displays activity against multiple laboratory and clinical isolate strains of herpes simplex virus 1 (HSV-1), HSV-2, and varicella zoster virus (VZV) in a plaque reduction assay (IC50s = 0.4-3.1 μg/ml). Penciclovir inhibits HSV-1 and HSV-2 replication (IC99s = 0.4 and 0.7 μg/ml, respectively) and DNA synthesis (IC50 = 0.04 μg/ml) in MRC-5 cells.

B2704 | Penciclovir DataSheet

Alternate Name/Synonyms: 2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one,BRL 39123

Appearance: White to off-white solid

Formulation:

CAS Number: 39809-25-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₀H₁₅N₅O₃

Molecular Weight: 253.26

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~0.33 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An antiviral agent

MDL Number: MFCD15142866

PubChem CID: 135398748

SMILES: C1=NC2=C(N1CCC(CO)CO)N=C(NC2=O)N

InChi: InChI=1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18)

InChi Key: JNTOCHDNEULJHD-UHFFFAOYSA-N